NMN is a not only a nucleotide, but also a precursor of nicotinamide adenine dinucleotide (NADH). This substance is naturally present in plant foods such as cabbages, cucumber and avocado.

According to some scientists, NMN doesn’t easily enter cells. Enzymes have to convert NMN into nicotinamide riboside (NR) before cell entry, these scientists claim. After entering, NR changes back into NMN. Maybe this theory holds water, maybe there some caveats. However, there is no denying that NMN’ bio-availability is excellent.

In cells, NADH is a cofactor for processes inside mitochondria, for the working mechanism of sirtuins and for a group of cellular repair proteins known as poly (ADP-ribose) polymerases (PARPs). PARPs play a vital role in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Resveratrol is a stilbenoid. It is a phytochemical which is naturally present in grapes, some berries, and peanuts. In cells, resveratrol inhibits the serine-threonine protein kinase AKT1. In this way, resveratrol imitates the effect of cellular starvation.

The bio-availability of resveratrol is low. To some degree, piperine, a natural compound of black pepper, can enhance the absorption of resveratrol. An even more effective way to increase the uptake of resveratrol by organisms is to incorporate this phytochemical in a phytosome nano-application. We used both technologies in the design of NMN Resveratrol Quercetin Cell Generator.

Quercetin, another component of NMN Resveratrol Quercetin Cell Generator, is a flavonol which can be found in a range of plant foods such as, apples, onions, and green tea. Quercetin is an oxidant and an inhibitor of the PI3K/AKT pathway – and through this mechanism also a downregulator of anti-apoptotic proteins. In addition, quercetin increases the bioavailability of resveratrol.

The bio-availability of quercetin is not much better than that of resveratrol, but in the design of NMN Resveratrol Quercetin Cell Generator this problem has been solved – again – by the application of phytosome technology.

Supplement Facts:
Serving size 2 vegetarian capsules. Amount per serving:
NMN powder(99% β-Nicotinamide Mononucleotide): 500 mg
Trans-resveratrol phytosome phosphatidylcholine complex (from Polygonum cuspidatum root extract): 200 mg
Quercetin phytosome phosphatidylcholine complex (as quercetin dihydrate): 30 mg
Piperine phytosome phosphatidylcholine complex (from Piper Nigrum): 2 mg

Ingredients: NMN powder, trans-resveratrol phytosome, quercetine phytosome, cellulose capsule, piperine phytosome.

Dosage and use:
Take two capsules daily, or as recommended by a healthcare practitioner. Do not exceed the recommended daily dose. Nutritional supplements should not be used as a substitute for a balanced diet.

Warnings:
-Do not take if you are pregnant.
-Keep out of reach of children.
-Do not exceed recommended dose.
-Do not purchase if outer seal/cap is broken or damaged.
-If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult with your medical practitioner first.
-A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
-Store tightly closed in a cool and dry place.

The post NMN Resveratrol Quercetin Cell Generator appeared first on Increase Lifespan.

Calcium alpha-ketoglutarate (Ca-AKG), as the name indicates, is the calcium salt of alpha-ketoglutarate, and it has excellent bio-availability. Additionally, alpha-ketoglutarate is an intermediate in the Krebs cycle, and it is a precursor of both the excitatory neurotransmitter glutamate and the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

Moreover, it plays a pivotal role in the removal of ammonia in the body in multiple organs, while also decreasing the levels of oxygen radicals like hydrogen peroxide. It’s worth noting that the body needs alpha-ketoglutarate for the conversion of proline to hydroxyproline, which is a component of type 1 collagen.

In fact, a study has shown that Calcium alpha-ketoglutarate (Ca-AKG) increases lifespan in mice: https://pubmed.ncbi.nlm.nih.gov/32877690/. Dr. David Sinclair uses Ca-AKG in his daily longevity stack. Additionally it has also been shown that patients with Hyperparathyroidism benefit from Calcium-alpha-ketoglutarate by reducing elevated concentration levels of phosphate in the blood.

If you want more in-depth information on Ca-AKG and longevity, you can visit: https://increaselifespan.net/2022/10/01/akg-alpha-ketoglutarate-longevity/.

Supplement Facts:
Serving size 1 vegetarian capsules. Amount per serving:
Calcium alpha-ketoglutarate: 450 mg

Ingredients: Calcium alpha-ketoglutarate, cellulose capsule.

Dosage and use:
Take one capsule each day in the morning, or as recommended by a healthcare practitioner. Do not exceed the recommended daily dose. Nutritional supplements should not be used as a substitute for a balanced diet.

Warnings:
-Do not take if you are pregnant.
-Keep out of reach of children.
-Do not exceed recommended dose.
-Do not purchase if outer seal/cap is broken or damaged.
-If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult with your medical practitioner first.
-A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
-Store tightly closed in a cool and dry place.

The post Calcium alpha-ketoglutarate (Ca-AKG) appeared first on Increase Lifespan.